Open Access Medical Books


Edited by Hani Almoallim .
Open Access .
564 pages .

Systemic lupus erythematosus (SLE) is a multi-systemic disease characterized by a wide variety of autoantibodies leading to highly heterogeneous clinical manifestations. 
SLE, or lupus, the Latin name for wolf is a unique, complex disease that comes with its own challenges; a challenge in diagnosis as lupus has a broad scope of symptoms, various clinical presentations & often does not follow a predictable course.
Another challenge is the management of Lupus; a healthcare professional maybe able to control the symptoms and disease activity with treatment, but it is not uncommon for health care professionals to encounter a lupus patient with numerous severe symptoms that are difficult to control. These challenges drove our efforts to write this book.
SLE book provides an overview of lupus and the elements involved in caring for patients with this disease. It addresses primarily healthcare professionals who deal with lupus patients. Each chapter of this book deals with a specific aspect of the disease. We addressed new advances in the pathogenesis of SLE. At the same time, we provided a comprehensive clinical guide for dealing with this disease.
Today, the prognosis for people with lupus is better than it was two decades ago; advances in research, improved treatments and the evolution in information resources helped many lupus patients to remain active and involved with life, family, and work.
We hope that this book can provide healthcare professionals with a solid grounding in this important disease so that they can provide the care to make an active and involved life a reality for women and men with lupus.
At the end, we would like to express our gratitude by thanking the team of internationally recognized authors who participated with us in the process of writing this book.

Dr. Hani Almoallim
Head Department of Medicine, Medical College, Umm Alqura University(UQU)
Associate Professor, Medical College, UQU
Consultant Rheumatologist, King Faisal Specialist Hospital and Research Center
Saudi Arabia


Part 1 of the Textbook : The Scientific Basis of Systemic Lupus Erythematosus .

 1 Genetics and Epigenetic in Systemic Lupus Erythematosus 3 Suad M. AlFadhli

 2 Cytokines and Systemic Lupus Erythematosus 53 Jose Miguel Urra and Miguel De La Torre

 3 Interferon and Apoptosis in Systemic Lupus Erythematosus 77 Daniel N. Clark and Brian D. Poole

 4 Fas Pathway of Cell Death and B Cell Dysregulation in SLE 97 Roberto Paganelli, Alessia Paganelli and Maria C. Turi

 5 Regulation of Nucleic Acid Sensing Toll-Like Receptors in Systemic Lupus Erythematosus 119 Cynthia A. Leifer and James C. Brooks

 6 Atherogenesis and Vascular Disease in SLE 137 Isabel Ferreira and José Delgado Alves

 7 Tyrosine-Based Monitoring of Glucocorticoid Therapy of Systemic Lupus Erythematosus 163 I. T. Rass

 8 Embryonic and Placental Damage Induced by Maternal Autoimmune Diseases - What Can We Learn from Experimental Models 185 Zivanit Ergaz and Asher Ornoy

 9 A Rabbit Model of Systemic Lupus Erythematosus, Useful for Studies of Neuropsychiatric SLE 201 Rose G. Mage and Geeta Rai

Part 2 of the Textbook : Clinical Aspects of Systemic Lupus Erythematosus .

 10 How to Avoid Delay in SLE Diagnosis and Management 219 Hani Almoallim, Esraa Bukhari, Waleed Amasaib and Rania Zaini

 11 Kidney Manifestation of Systemic Lupus Erythematosus 243 Wael Habhab

 12 New Therapeutic Strategies in Lupus Nephritis 255 Natasha Jordan and Yousuf Karim

 13 Cardiovascular Involvement in Systemic Lupus Erythematosus 273 Sultana Abdulaziz, Yahya AlGhamdi, Mohammed Samannodi and Mohammed Shabrawishi

 14 Pulmonary Manifestations of Systemic Lupus Erythematosus 313 Abdul Ghafoor Gari, Amr Telmesani and Raad Alwithenani

 15 Approach to Patients with SLE Presenting with Neurological Findings 337 Alkhotani Amal

 16 The Pathophysiology of Systemic Lupus Erythematosus and the Nervous System 353 Joel M. Oster

 17 Haematological Manifestations in Systemic Lupus Erythematosus 363 Nahid Janoudi and Ekhlas Samir Bardisi

 18 Lymphoproliferative Disorders in Patients with Systemic Lupus Erythematosus 383 Carlos Panizo and Ricardo García-Muñoz

 19 Infections and Systemic Lupus Erythematosus 407 C. Alejandro Arce-Salinas and Pablo Villaseñor-Ovies

 20 Anti-Tumour Necrosis Factor-α Induced Systemic Lupus Erythematosus 454 Hani Almoallim and Hadeel Khadawardi

Part 3 of the Textbook : Pregnancy and Systemic Lupus Erythematosus .

 21 SLE and Pregnancy 457 Hanan Al-Osaimi and Suvarnaraju Yelamanchili

 22 Management of Pregnant Lupus 483 Hanan Al-Osaimi and Suvarnaraju Yelamanchili

 23 Neonatal Lupus Erythematosus (NLE) 507 Hanan Al-Osaimi and Suvarnaraju Yelamanchili

 24 Maternal SLE Influence in Fetal Development: Immune and Endocrine Systems 531 Emma Rodriguez, Juan Gabriel Juarez-Rojas and Luis Felipe Montaño .

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Published by: Unknown - Sunday, June 9, 2013


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