Open Access Medical Books



Edited by Jean M. Elwing and Ralph J. Panos .

242 pages .
Open Access .
ISBN 978-953-51-1165-8 .

When Viktorija Zgela, Senior Commissioning Editor, InTech, approached us in the spring of 2012 to assist with editing a book about pulmonary hypertension that was already underway, little did we know what we were getting into. The work was already in progress with authors assigned to topics, research and writing started. Indeed, we stepped into fast moving process that had long passed the conceptual stage and was well into realization. We greatly thank Ms. Zgela and her colleagues at InTech for their patience and assistance guiding us through the process to bring this work to publication. Without their assistance, this book would never have made it to the presses.
We are greatly indebted to all the chapter authors who have persevered through multiple revisions, delays, and countless nights and weekends revising and editing. This final work reveals the fruit of all their labor.
In the initial chapter, Pulmonary Arterial Hypertension: An Overview, Saleem Sharieff presents a comprehensive synopsis of the epidemiologic, clinical, histopathologic, and therapy of PAH. Next, Dimitar Sajkov, Bliegh Mupunga, Jeffrey J. Bowden, and Nikolai Petrovsky comprehensively review World Health Organization group III PH in Pulmonary Hypertension in Chronic Lung Diseases and/or Hypoxia. The focus then shifts to the cellular and biochemical derangements underlying the pathophysiology of PH which are summarized by Rajamma Mathew in the Pathogenesis of Pulmonary Hypertension. Specific mechanisms that have been implicated in the pathogenesis of PH are presented by Junko Maruyama, Ayumu Yokochi, Erquan Zhang, Hirohumi Sawada, Kazuo Maruyama in Nitric Oxide in the Pathophysiology and Treatment of Pulmonary Hypertension, and Aureliano Hernández and Rafael A. Areiza in Angiogenesis and Pulmonary Hypertension. The focus then shifts to PH associated with thromboembolic disease. We discuss PH that occurs in association with acute thromboembolism in Acute Thromboembolic Pulmonary Hypertension.
Mehdi Badidi and M’Barek Nazi present a comprehensive overview of PH caused by chronic thromboembolic disease in Chronic Thromboembolic Pulmonary Hypertension. Juan C.Grignola, María J. Ruiz-Cano, Juan P. Salisbury, Gabriela Pascal, Pablo Curbelo, and Pilar Escribano present a detailed overview of the physiologic assessment of patients with chronic thromboembolic disease prior to surgical pulmonary endarterectomy in Assessment of Diagnostic Testing to Guide the Surgical Management of Chronic Thromboembolic Pulmonary Hypertension. Finally, Henry Liu, Philip L. Kalarickal, Yiru Tong, Daisuke Inui, Michael J Yarborough, Kavitha A. Mathew, Amanda Gelineau, and Charles Fox comprehensively review the clinical perioperative evaluation and management of patients with PH in Perioperative Considerations of Patients with Pulmonary Hypertension.
We thank all the editors at InTech and all the authors for their diligence and effort in producing and writing this text. Most importantly, we thank our spouses for their lenience and sympathetic tolerance of the long weekends and late nights writing, editing, reading, and revising this work to bring it to publication.

Jean M. Elwing
Ralph J. Panos


 1 Pulmonary Arterial Hypertension: An Overview 1 Dr Saleem Sharieff MBBS, FCPS, FRCPC

2 Pulmonary Hypertension in Chronic Lung Diseases and/or Hypoxia 21 Dimitar Sajkov, Bliegh Mupunga, Jeffrey J. Bowden and Nikolai Petrovsky

 3 Pathogenesis of Pulmonary Hypertension 47 Rajamma Mathew

 4 Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension 75 Junko Maruyama, Ayumu Yokochi, Erquan Zhang, Hirofumi Sawada and Kazuo Maruyama

 5 Angiogenesis and Pulmonary Hypertension 103 Aureliano Hernández and Rafael A. Areiza

 6 Acute Thromboembolic Pulmonary Hypertension 117 Jean M. Elwing and Ralph J. Panos

 7 Chronic Thromboembolic Pulmonary Hypertension 143 Mehdi Badidi and M’Barek Nazi

 8 Assessment of Diagnostic Testing to Guide the Surgical Management of Chronic Thromboembolic Pulmonary Hypertension 169 Juan C Grignola, María José Ruiz-Cano, Juan Pablo Salisbury, Gabriela Pascal, Pablo Curbelo and Pilar Escribano-Subías

 9 Perioperative Considerations of Patients with Pulmonary Hypertension 195 Henry Liu, Philip L. Kalarickal, Yiru Tong, Daisuke Inui, Michael J. Yarborough, Kavitha A. Mathew, Amanda Gelineau, Alan D. Kaye and Charles Fox .

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Published by: Unknown - Sunday, July 21, 2013


  1. Hypertension is a major, worldwide health problem owing to its high prevalence and association with increased morbidity and mortality. Hypertension is a key risk factor for cardiovascular morbidity and mortality and is a leading cause of end-stage renal disease. Hypertensive and an equivalent percentage suffers from prehypertension; evidence shows that individuals with prehypertension are at particular risk of developing overt hypertension.