Open Access Medical Books



Edited by Deepa Bhartiya and Nibedita Lenka .

638 pages . 
Open Access .
ISBN 978-953-51-1192-4 .

Pluripotency is basically defined as the potential to give rise to all three germ layer derivatives reflecting to 200 odd cell types present in the body, and except the extra-embryonic cell types. It could be either (i) inherent as seen in case of embryonic stem (ES) cells derived from the inner cell mass of blastocyst stage embryo, embryonic/primordial germ (EG/PG) cells derived from developing gonads, embronal carcinoma (EC) cells or (ii) acquired. The latter category includes the cells from adult tissues reprogrammed to attain the pluripotent state and functioning similar to ES cells. This could be achieved either by somatic cell nuclear transfer (SCNT) or by incorporating a set of transcription factors specific to ES cells into somatic cells and their transient activation leading to induction of pluripotency in them, the latter being designated as induced pluruipotent stem cells (iPSCs) pioneered by Dr. Shinya Yamanaka (the recipient of Nobel Prize in Physiology / Medicine for the year 2012 along with Sir Dr. John Gordon, the father of reprogramming phenomenon).
Undoubtedly the recent progress in Stem Cells research field has opened up a wider horizon with various interesting avenues for explorations in basic Biology and Development and on successful broad spectral implication of stem cells in cell replacement therapy, gene therapy, live stock improvement and tissue engineering as well as in pharmaceutical industries.
However, a priori requirement is to have the mechanistic understanding and address the safety vs. the efficacy issue including the ethical concerns. In an effort in this line, the book, “Pluripotent Stem Cells” is a compendium addressing the aforesaid aspects. Indeed wide gamut of topics has been covered in the book under various sections with contributions from experts in the stated field concerning diverse aspects of pluripotent stem cells. We hope that the book would add up to the existing knowledge on pluripotent stem cells.

Dr. Deepa Bhartiya
National Institute for Research in Reproductive Health (NIRRH),

Dr. Nibedita Lenka
National Centre for Cell Science,
Pune University Campus,
Ganeshkhind, Pune, India


Section 1 Pluripotent Stem Cells: The Genesis and Means .

 1 An Overview of Pluripotent Stem Cells 3 Deepa Bhartiya, Punam Nagvenkar, Kalpana Sriraman and Ambreen Shaikh

 2 Pluripotent Adult Stem Cells: A Potential Revolution in Regenerative Medicine and Tissue Engineering 25 Tsz Kin Ng, Daniel Pelaez, Veronica R. Fortino, Jordan Greenberg and Herman S. Cheung

 3 De-Differentiation of Somatic Cells to a Pluripotent State 39 Cristiane V. Wenceslau, Irina Kerkis, Nelson F. Lizier and Alexandre Kerkis

 4 The Dark Side of Pluripotency – Cancer Stem Cell 65 Patricia Ng and Wang Cheng-I

 5 Conditions and Techniques for Mouse Embryonic Stem Cell Derivation and Culture 85 Kun-Hsiung Lee

 6 Human Testis–Derived Pluripotent Cells and Induced Pluripotent Stem Cells 117 Hideyuki Kobayashi, Koichi Nagao and Koichi Nakajima

 7 Generation of Induced Pluripotent Stem Cells from Dental Pulp Somatic Cells 131 Nelson F. Lizier, Irina Kerkis and Cristiane V. Wenceslau

Section 2 Mechanistic Underpinning .

 8 Molecular Mechanisms Underlying Pluripotency 153 Erhard Bieberich and Guanghu Wang

 9 Stem Cells and Epigenetic Reprogramming 179 Perla Cota, Mehdi Shafa and Derrick E. Rancourt

 10 Epigenetic Reprogramming in Stem Cells 205 Richard L. Eckert, Yasin Kizilyer and Candace L. Kerr

 11 Multiple Paths to Reprogramming 227 Antonio Lo Nigro and Catherine M. Verfaillie

 12 Induced Pluripotent Stem Cells: Current and Emerging Technologies 263 Jacob Kimmel and Kiminobu Sugaya

 13 Molecular Mechanisms of Embryonic Stem Cell Pluripotency 283 Guofeng Han, Hongtao Wang and Jijun Hao

 14 Epigenetic Instability in Embryonic Stem Cells 301 Takuro Horii and Izuho Hatada

 15 Function of KLF4 in Stem Cell Biology 317 Ying Shi and Walden Ai

 16 β1,4-Galactosyltransferases, Potential Modifiers of Stem Cell Pluripotency and Differentiation 345 Michael Wassler

Section 3 Therapeutic Implications and Ethical Concerns .

 17 Advances in Stem Cell Therapies 375 Joel Sng and Thomas Lufkin

18 Embryonic Stem Cell Therapy – From Bench to Bed 397 Laura E. Sperling

 19 Disease Models for the Genetic Cardiac Diseases 415 Mari Pekkanen-Mattila, Kristiina Rajala and Katriina Aalto-Setälä

 20 Pluripotent Stem Cells to Model Human Cardiac Diseases 439 Calvin C. Sheng and Charles C. Hong

 21 Pluripotent Stem Cells for Cardiac Cell Therapy: The Application of Cell Sheet Technology 459 Hidetoshi Masumoto and Jun K. Yamashita

 22 Human Pluripotent Stem Cells Modeling Neurodegenerative Diseases 477 Roxana Nat, Andreas Eigentler and Georg Dechant

 23 Induced Pluripotent Stem Cells as a Source of Hepatocytes 517 Minoru Tomizawa, Fuminobu Shinozaki, Takao Sugiyama, Shigenori Yamamoto, Makoto Sueishi and Takanobu Yoshida

 24 Induced Pluripotent Stem Cells: Therapeutic Applications in Monogenic and Metabolic Diseases, and Regulatory and Bioethical Considerations 529 Antonio Liras, Cristina Segovia and Aline S. Gabán

 25 Safety Assessment of Reprogrammed Cells Prior to Clinical Applications: Potential Approaches to Eliminate Teratoma Formation 555 Juan Carlos Polanco and Andrew L. Laslett

 26 Stem Cells in Tissue Engineering 567 Shohreh Mashayekhan, Maryam Hajiabbas and Ali Fallah

 27 Ethical Considerations on Stem Cell Research 603 Andreas M. Weiss, Michael Breitenbach, Mark Rinnerthaler and Günter Virt .

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Published by: Unknown - Sunday, August 21, 2016


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