Open Access Medical Books



Edited by Sabina Janciauskiene .

188 pages .
Open Access .
ISBN 978-953-51-1185-6 .

Acute phase proteins (APPs) are a large group of proteins synthesized by the liver cells and released into the bloodstream in response to a variety of stressors as part of the acute phase of the inflammatory reaction. Proteins with a transient increase in synthesis and plasma concentration are called positive, whereas proteins whose synthesis decreases are referred to as negative APPs. The synthesis of the APP is thought to be mainly regulated by inflammatory cytokines, such as interleukin-6, interleukin-1 and tumor necrosis factor.
APPs functioning as protease inhibitors, enzymes, transport proteins, coagulation proteins, and modulators of the host’s immune response, and play a role in the restoration of homeostasis after injury or infection. APPs act in a time, concentration and molecular conformation- dependent manner on a variety of cells involved in early and late stages of inflammation. APPs can directly contribute to the enhancement and/or the suppression of inflammation at different points in its evolution. The administration of specific APPs has been shown to switch the pro-inflammatory to the anti-inflammatory pathways necessary for the resolution of inflammation in vitro and in vivo. Nevertheless, the biological function of most APPs has not been totally elucidated. It is also not clear what functional advantages may arise from the rapid changes in the blood profile of APPs as a group.
Thus, the magnitude and rapidity of the changes in the specific profile of APPs, together with their short half-life, suggest a particularly important role for these proteins in the establishment of host defense. The functional activities of specific APPs and their quantification during the course of acute and chronic inflammation are discussed in this book.

Prof. Dr. Sabina Janciauskiene
Department of Respiratory Medicine,
Hannover Medical School,
Hannover, Germany


 1 Immunoregulatory Properties of Acute Phase Proteins — Specific Focus on α1-Antitrypsin 1 S. Janciauskiene, S. Wrenger and T. Welte

 2 Inflammation and Acute Phase Proteins in Haemostasis 31 Simon J. Davidson

 3 The Role of Haptoglobin and Its Genetic Polymorphism in Cancer: A Review 55 Maria Clara Bicho, Alda Pereira da Silva, Rui Medeiros and Manuel Bicho

 4 Role of SAA in Promoting Endothelial Activation: Inhibition by High-Density Lipoprotein 77 Xiaosuo Wang, Xiaoping Cai, Saul Benedict Freedman and Paul K. Witting

 5 The Use of Acute Phase Proteins as Biomarkers of Diseases in Cattle and Swine 103 Csilla Tóthová, Oskar Nagy and Gabriel Kováč

 6 Molecular Aspects of Human Alpha-1 Acid Glycoprotein — Structure and Function 139 Kazuaki Taguchi, Koji Nishi, Victor Tuan Giam Chuang, Toru Maruyama and Masaki Otagiri

 7 Unique Assembly Structure of Human Haptoglobin Phenotypes 1-1, 2-1, and 2-2 and a Predominant Hp 1 Allele Hypothesis 163 Mikael Larsson, Tsai-Mu Cheng, Cheng-Yu Chen and Simon J. T. Mao 

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Published by: Unknown - Monday, November 4, 2013

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